平继辉
学科：预防兽医学
地址：南京农业大学、动物医学院、免疫研究所电话：+86-025-84396466-8041
传真：+86-025-84395166
邮箱：jihui.ping@njau.edu.cn
个人情况简介：
南京农业大学高层次引进人才，教授。2008年毕业于南京农业大学获博士学位，2008年12月至2011年7月加拿大渥太华大学(University of Ottawa)博士后，2011年7月至2014年7月美国威斯康星大学麦迪逊分校(University of Wisconsin-Madison)博士后，2014年8月2016年8月美国威斯康星大学麦迪逊分校助理科学家(Assistant Scientist)。2016年 5月至今南京农业大学动物医学院教授。长期致力于流感病毒的遗传进化、致病性、跨宿主传播及相关分子机制、病毒抗原变异的分子基础及抗原变异预测、高产高效流感疫苗等方向研究并取得了一系列的创新性研究成果，在Nature Communications, PNAS, Nature Microbiology, Journal of Virology等杂志发表SCI文章15篇，申请国际专利两项。先后参与科研项目7项，包括加拿大CIHR项目2项、美国CRIP、盖茨基金项目、WARF项目和ASPR项目4项以及“十三五“国家重点研发计划重点专项1项。
研究兴趣：
流感病毒的分子遗传进化。
流感病毒的致病性和跨宿主传播的分子机制。
流感病毒抗原变异的分子机制及抗原变异预测。
流感疫苗研发。
外来病与野生动物病毒性疾病研究。
代表论著：
•Jihui Ping, Tiago J. S. Lopes, Gabriele Neumann, Yoshihiro Kawaoka, Development of high-yield influenza B virus vaccine viruses, 2016, Proceedings of the National Academy of Sciences (Accepted).
•Chengjun Li*, Masato Hatta*, David F. Burke*, Jihui Ping*,Ying Zhang*, Makoto Ozawa, Andrew S. Taft, Subash C. Das, Anthony P. Hanson, Jiasheng Song, Masaki Imai, Peter R. Wilker, Tokiko Watanabe, Shinji Watanabe, Mutsumi Ito, Kiyoko Iwatsuki-Horimoto, Colin A. Russell, Sarah L. James, Eugene Skepner, Eileen A. Maher, Gabriele Neumann, Alexander I. Klimov, Anne Kelso, John McCauley, Dayan Wang, YuelongShu, Masato Tashiro, Nancy J. Cox, Derek J. Smith, and Yoshihiro Kawaoka. Selection of antigenic variants representing a new cluster of pandemic (H1N1) 2009 influenza viruses. Nature Microbiology, doi: 10.1038/nmicrobiol. 2016.58 (Co-first author)
•Jihui Ping, Tiago J. S. Lopes, Chairul A. Nidom, ElodieGhedin, Catherine A. Macken, Adam Fitch, Masaki Imai, Eileen A. Maher, Gabriele Neumann, Yoshihiro Kawaoka. Development of high-yield influenza A virus vaccine viruses. Nature Communications. 6:8148 doi: 10.1038/ncomms9148 (2015).
•YuanlongHou, Xiaoyan Wang, Zhihai Lei,Jihui Ping, jiajian Liu, Zhiyu Ma, Zheng Zhang, CuicuiJia, Mengmeng Jin, Xiang Li, Xiaoliang Li, Shaoqiu Chen, YingfangLv, YingdongGao, Wei Jia, and Juan Su. Heat-Stress-Induced Metabolic Changes and Altered Male Reproductive Function. J Proteome Res. 2015 Mar 6;14(3):1495-503. doi: 10.1021/pr501312t.
•Dankar SK, Miranda E, Forbes NE, Pelchat M, Tavassoli A, Selman M, Jihui Ping,Jia J, Brown EG. Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30. Virol J. 2013 Jul 25;10:243. doi: 10.1186/1743-422X-10-243.
•Tokiko Watanabe, Maki Kiso, Satoshi Fukuyama, Noriko Nakajima, Masaki Imai, Shinya Yamada, Shin Murakami, SeiyaYamayoshi, Kiyoko Iwatsuki-Horimoto, Yoshihiro Sakoda, Emi Takashita, Ryan McBride, Takeshi Noda, Masato Hatta, Hirotaka Imai, Dongming Zhao, Noriko Kishida, Masayuki Shirakura, Robert P. de Vries, ShintaroShichinohe, Masatoshi Okamatsu, Tomokazu Tamura, Yuriko Tomita, Naomi Fujimoto, Kazue Goto, Hiroaki Katsura, Eiryo Kawakami, Izumi Ishikawa, Shinji Watanabe, Mutsumi Ito, Yuko Sakai-Tagawa, Yukihiko Sugita, RyutaUraki, Reina Yamaji, Amie J. Eisfeld, GongxunZhong, Shufang Fan, Jihui Ping, Eileen A. Maher, Anthony Hanson, Yuko Uchida, Takehiko Saito,Makoto Ozawa, Gabriele Neumann,Hiroshi Kida, Takato Odagiri, James C. Paulson,HidekiHasegawa,MasatoTashiro& Yoshihiro Kawaoka Characterization of H7N9 influenza A viruses isolated from humans. Nature. 2013 Sep 26;501(7468):551-5. doi: 10.1038/nature12392.
•Jihui Ping, Mohammed Selman, Shaun Tyler, Nicole Forbes, LiyaKeleta, Earl Brown, Low pathogenic avian influenza A/Turkey/Ontario/6213/1966(H5N1) is the progenitor of highly pathogenic A/Turkey/Ontario/7732/1966(H5N9). Journal of General virology; 2012 Aug; 93 (Pt 8): 1649-57
•Nicole E. Forbes, Jihui Ping, Samar K. Dankar, Jian-Jun Jia, Mohammed Selman, LiyaKeleta, Yan Zhou, Earl G. Brown, Multifunctional Adaptive NS1 Mutations Are Selected upon Human Influenza Virus Evolution in the Mouse. 2012, PloS ONE, Volume 7 (2): e31839
•Jihui Ping, L. Keleta, N. Forbes, S. Dankar, W. Stecho, S. Tyler, Y. Zhou, L. Babiuk, H. Weingartl, R. A. Halpin, A. Boyne, J. Bera, J. Hostetler, N. Fedorova, K. Proudfoot, D. Katzel, T.B. Stockwell, E. Ghedin, D. Spiro and e. G. Brown, Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse. 2011, PLoS ONE, Volume 6(6): e217403.
•Samar K. Dankar, Shuai Wang, Jihui Ping, Nicole E. Forbes, LiyaKeleta, Earl G. Brown. Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence. Virol J. 2011 Jan 12; 8(1):13
•Jihui Ping, Samar K. Dankar, Nicole E. Forbes, LiyaKeleta, Yan Zhou, Shaun Tyler Earl G. Brown, PB2 and HA Mutations are Major Determinants of Host Range and Virulence in Mouse-Adapted Influenza A Virus. Journal of virology. 2010, (84), 10606-10618.
•Jihui Ping, Chengjun Li, Guohua Deng, Yongping Jiang, GuobinTian, Shuxia Zhang, Zhigao Bu, Hualan Chen. Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody. Biochem. Biophys.Res. Commun. 2008, (371):168-171
•Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, GuobinTian, Kangzhen Yu, Zhigao Bu, Hualan Chen. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochem. Biophys. Res. Commun. 2008, (372): 293-297
•Juan Su, Zhihai Lei, Wenlong Zhang, HongmeiNing, Jihui Ping. Distribution of orexin B and its relationship with GnRH in the pig hypothalamus. Research in Veterinary Science. 2008,(85): 315-323
•Chengjun Li, Kangzhen Yu, GuobinTian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, Hualan Chen. Evolution of H9N2 influenza viruses from domestic poultry in Mainland China.Virology. 2005 Sep 15;340(1):70-83.
专利：
•Mutations in the influenza A virus NS1 gene and use thereof. Inventors: E. G Brown, Nicole Forbes and Jihui Ping. US and Canadian Patents filed. July 10, 2010. NO.20110070254
•High titer recombinant influenza viruses with enhanced replication in MDCK or Vero cells or Eggs. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. US patent NO: P130287US02. Europe patent NO: P130287EU01, Janpan patent NO: P130287JP01, Australia patent NO: P130287AU01.
•Improved influenza B viruses replication for vaccine development. Inventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. (In progress, Ref No: P150360WO01).
•Improved influenza vaccines. Inventors: Yoshihiro Kawaoka, Derel Smith, Chengjun Li, Gabriele Neumann, Jihui Ping, Eileen Maher, Shufang Fan, David Burke, RonaldusFouchier, Ana Mosterin Hopping, Sarah L. James, Bjorn F. Koel, Samuel H. Wilks, Judith M. Fonville, Ramona Mogling (In processing).
•Improved influenza virus replication by inhibiting microRNA Let-7C binding to influenza vRNA and mRNA. nventors: Yoshihiro Kawaoka, Gabriele Neumann and Jihui Ping. (In progress, Ref No: P150345US02).